Senior Laboratory Technologist - Clinical Genomics

OverviewThe Laboratory Technologist will undertake a variety of laboratory procedures of technical nature. Under the supervision of the Genomics Laboratory Supervisor, you will be handling sensitive equipment to analyse samples or substances, conduct tests and report findings to the line manager.The job duties will also include a combination of the following responsibilities: extensive and complex steps requiring manual manipulation and pipetting, close monitoring and control, evaluation of data, and careful and accurate work.ResponsibilitiesPerform nucleic acid extraction.Perform manual and automated extraction and purification of DNA/RNA from various clinical specimens, including blood, tissue, and bone marrow.Ability to independently prepare DNA libraries for high-throughput sequencing and utilize sequencing platforms for basic genomic analysis.Operate and troubleshoot Next Generation Sequencing equipment.Perform PCR (including RT-PCR and fluorescent PCR).Perform QA/QC procedures and documentation.Perform troubleshooting to solve problems as they arise.Assist with training of laboratory medical technicians in new methods to implement clinical testing and workflows.Assist in maintaining CAP/ISO Standards and working with the quality department to keep the laboratory in compliance with regulations as they relate to test validation.Reading of pertinent literature related to the specialty to maintain current knowledge in this dynamic, rapidly evolving, field.Ensure validity of laboratory data reported.Participate in validation activities and participate in daily operation of the lab platforms.Participate in experimental design and instrument set-up.Contribute to maintaining a Quality environment and participate actively in SOP writing and revision.Develop next-generation sequencing sample prep methods, both by utilizing standard molecular biology processes and creating novel solutions.Coordinate and support all stages of the transition of new products from development to product release, such as validating processes, establishing quality controls.Perform duties assigned by Line manager.Aware of GCLP and GCP that apply to their work and be fully aware of the function they are to perform.Responsible for recording raw data promptly, accurately and in compliance with GCLP and are responsible for the quality of their data.Responsible for following the instructions given in the clinical protocol, analytical plans and SOPs.QualificationsBachelor’s degree or above in Medical Laboratory or other related majors is preferred.Experience in automated workstation system.Fluent in English oral and written.Good communication skills.Molecular Biology with genomics background.Experience in Next Generation Sequencing (NGS) and/or Microarray techniques preferred.Minimum 2 years of experience in genomics.Experience in CAP or ISO15189 certified laboratory is preferred.DOH License.